Significance Capital Management, led by founder and CIO Ryan Isherwood, and co-portfolio manager Michael W Klenn, has launched, positioning itself as an investment firm specialising in capturing opportunities around market inflection points.

Isherwood and Klenn have over a decade of experience building momentum-driven strategies at Timpani Capital Management and later Calamos Investments.

Significance Capital’s strategy combines fundamental, quantitative, and technical analysis to identify shifts in market cycles, particularly focusing on momentum and mean reversion. According to the firm, its proprietary models aim to detect early signals of changes in investor behaviour, such as when buying activity slows before aggressive selling begins, enabling the team to position portfolios to capture upside while managing risk during volatile periods.

“Our approach seeks to identify asymmetric opportunities across equity and other asset classes by analysing the interplay between momentum and mean reversion,” said Isherwood. “Markets move through cycles, and recognising the turning points between those regimes is where we see significant potential.”

Klenn added that the firm’s investment process targets extremes in market sentiment, aiming to generate alpha by focusing on stocks with strong momentum or deeply out-of-favour assets, while combining bottom-up research with quantitative and technical signals to manage risk effectively.